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Monotherapy versus combination therapy for sepsis due to multidrug-resistant Acinetobacter baumannii: analysis of a multicentre prospective cohort

2014; Oxford University Press; Volume: 69; Issue: 11 Linguagem: Inglês

10.1093/jac/dku233

1460-2091

Luis Eduardo López-Cortés, José Miguel Cisneros, Felipe Fernández-Cuenca, Germán Bou, María Tomás, José Garnacho‐Montero, Álvaro Pascual, Luis Martínez‐Martínez, Jordi Vilà, Jerónimo Pachón, Jesús Rodríguez‐Baño, Antonio Sánchez-Porto, Lisímaco Vallejo Cuéllar, B. F. Perez, Joshua Chao, Bryan Ortega, E. C. Mansilla, José Javier García Irure, Alfonso del Arco, Javier de la Torre, Carlos García Cardona, Vicente Abril, Joseph Vilaró Pujals, Marian Navarro Aguirre, José Antonio Jiménez Alfaro, Carmen Jaca, Paul Casanova, Francisca Guerreo, Teresa Nebreda-Mayoral, María José Fernández Calavia, Enrique Marco de Lucas, Alfredo Zorraquino, Eugenio Garduño Eseverri, Luis Sanchez, Ana Fleites Gutiérrez, Azucena Rodríguez-Guardado, José María García-Arenzana Anguera, Serafín López Palmero, Manuel Rodríguez Maresca, Fernando García Garrote, J. V. Otero, E. V. Verdu, F. R. Lopez, F. P. Sanchez, E. Ferrer Vizoso, Mercè Gurguí, R. Pericás, P.M. Olaechea Astigarraga, Rafael Ayarza Igartua, María Romero, Enrique Ruiz de Gopegui Bordes, M. I. Sanchez Romero, Jesús García Mata, M.J. Goyanes, J. H. Quero, Trinidad Escobar Lara, Frederic Ballester Bastardie, Simona Iftimie, María Isabel Galán Navarro, María de la Luz Cádiz‐Gurrea, Carmen Amores Antequera, María Pilar Romero‐Gómez, Constanza Salas, Jordi Cuquet Peragosa, Susana Hernando Real, P. A. Carrero Gonzalez, María Angeles Pallarés González, Sergio Rodríguez Fernández, Mikel Rojo, Fé Tubau, Estela Álvarez, María Ortega Torres, Salvador Giner Almaraz, E. Hortelano, F. C. Sanchez, Ana García Reyne, Juan Pablo Horcajada, Concepción Segura, G. Dorado, R. Y. Escudero, María Elena Dorta Hung, Cristóbal del Rosario Q,

Antibiotics Pharmacokinetics and Efficacy

BackgroundTreatment of multidrug-resistant Acinetobacter baumannii (MDRAB) infection presents a challenge because of the scarcity of available options. Even though combination therapy (CT) is frequently used in clinical practice, data are needed to support its use instead of monotherapy (MT).