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Microwave-assisted cycloaddition reactions

2009; Royal Society of Chemistry; Volume: 39; Issue: 5 Linguagem: Inglês

10.1039/b815717k

1460-4744

Prasad Appukkuttan, Vaibhav P. Mehta, Erik V. Van der Eycken,

Chemical Synthesis and Analysis

Cycloaddition reactions belong to one of the most well-investigated and widely used reactions in synthetic organic chemistry for the construction of (hetero)cyclic compounds in a single-step operation. In this tutorial review, a select number of examples of some [3+2] cycloadditions, i.e. for 1,2,3-triazole formation, as well as of some [4+2] and [2+2] cycloadditions are reviewed, where it has been proven that the application of microwave irradiation has a profound influence on the outcome of the reaction.