Reprogrammed Cells for Disease Modeling and Regenerative Medicine
2013; Annual Reviews; Volume: 64; Issue: 1 Linguagem: Inglês
10.1146/annurev-med-050311-163324
ISSN1545-326X
Autores Tópico(s)Zebrafish Biomedical Research Applications
ResumoThe conversion of somatic cells into pluripotent cells is transforming the way diseases are researched and treated. Induced pluripotent stem (iPS) cells' promise may soon be realized in the field of hematology, as hematopoietic stem cell transplants are already commonplace in clinics around the world. We provide a current comparison between induced pluripotent and embryonic stem cells, describe progress toward modeling hematological disorders using iPS cells, and illustrate the hurdles that must be overcome before iPS cell therapies will be available in clinics.
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