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Protein S deficiency: a clinical perspective

2008; Wiley; Volume: 14; Issue: 6 Linguagem: Inglês

10.1111/j.1365-2516.2008.01775.x

1365-2516

Min Ki ten Kate, J. van der Meer,

Cardiovascular Issues in Pregnancy

Protein S (PS) is an extensively studied protein with an important function in the down-regulation of thrombin generation. Because of the presence of a pseudogene and two different forms of PS in plasma, a bound and a free form, it is one of the most difficult thrombophilias to study. A deficiency of PS predisposes subjects to (recurrent) venous thromboembolism (VTE) and foetal loss. However, the conundrum of diagnosing PS deficiency has led to conflicting reports of PS as a risk factor for VTE. In this review, we aim to present a clinical perspective of PS deficiency.