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Artigo Revisado por pares
BIBTEX RIS

First Dynamic Kinetic Resolution of Racemic α‐Amino Aldehydes

1995; Wiley; Volume: 34; Issue: 9 Linguagem: Inglês

10.1002/anie.199510231

ISSN

1521-3773

Autores

Tobias Rein, Reinhard Kreuder, Paultheo von Zezschwitz, Christian Wulff, Oliver Reiser,

Tópico(s)

Phosphorus compounds and reactions

Resumo

The configurational instability of α-amino aldehydes is an advantage for dynamic kinetic resolution (that is, kinetic resolutions with in situ epimerization of the substrate) through the Horner–Wadsworth–Emmons reaction. For instance, rac-1 and the chiral phosphonate 2 yield the ester (S)-3 with 90% de. Bn = PhCH2, Ts = H3CC6H4SO2, R = CF3CH2, R′ = (−)-8-phenylmenthyl.

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