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Human interleukin 17–producing cells originate from a CD161+CD4+ T cell precursor

2008; Rockefeller University Press; Volume: 205; Issue: 8 Linguagem: Inglês

10.1084/jem.20080397

1540-9538

Lorenzo Cosmi, Raffaele De Palma, Veronica Santarlasci, Laura Maggi, Manuela Capone, Francesca Frosali, Gabriella Rodolico, Valentina Querci, Gianfranco Abbate, Roberta Angeli, Liberato Berrino, Massimiliano Fambrini, Marzia Caproni, Francesco Tonelli, Elena Lazzeri, Paola Parronchi, Francesco Liotta, Enrico Maggi, Sergio Romagnani, Francesco Annunziato,

Psoriasis: Treatment and Pathogenesis

We demonstrate that CD161 is a highly up-regulated gene in human interleukin (IL) 17 T helper cell (Th17) clones and that all IL-17-producing cells are contained in the CD161(+) fraction of CD4(+) T cells present in the circulation or in inflamed tissues, although they are not CD1-restricted natural killer T cells. More importantly, we show that all IL-17-producing cells originate from CD161(+) naive CD4(+) T cells of umbilical cord blood, as well as of the postnatal thymus, in response to the combined activity of IL-1 beta and IL-23. These findings implicate CD161 as a novel surface marker for human Th17 cells and demonstrate the exclusive origin of these cells from a CD161(+)CD4(+) T cell progenitor.