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Anti-inflammatory and Radical Scavenge Effects of Arctium lappa

1996; World Scientific; Volume: 24; Issue: 02 Linguagem: Inglês

10.1142/s0192415x96000177

1793-6853

Chun‐Ching Lin, Jer‐Min Lin, Jeng-Jer Yang, Shu-Chuan Chuang, Takashi Ujiie,

Phytochemistry and Biological Activities

The effects of Arctium lappa L. (root) on anti-inflammatory and free radical scavenger activity were investigated. Subcutaneous administration of A. lappa crude extract significantly decreased carrageenan-induced rat paw edema. When simultaneously treated with CCl4, it produced pronounced activities against CCl4-induced acute liver damage. The free radical scavenging activity of its crude extract was also examined by means of an electron spin resonance (ESR) spectrometer. The IC50 of A. lappa extract on superoxide and hydroxyl radical scavenger activity was 2.06 mg/m 11.8 mg/m1, respectively. These findings suggest that Arctium lappa possess free radical scavenging activity. The inhibitory effects on carrageenan-induced paw edema and CCl 4 -induced hepatotoxicity could be due to the scavenging effect of A. lappa.