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Effects of human albumin and serum on the in vitro bactericidal activity of cefditoren against penicillin-resistant Streptococcus pneumoniae

2007; Oxford University Press; Volume: 60; Issue: 1 Linguagem: Inglês

10.1093/jac/dkm115

1460-2091

David Sevillano, María-José Giménez, Luís Alou, L. Aguilar, Fabio Cafini, M. Torrico, Natalia González, O. Echeverría, Pilar Coronel, J. Prieto,

Streptococcal Infections and Treatments

ObjectivesAttempts to interpret antibiotic pharmacodynamics using reported protein binding may underestimate true activity. To elucidate this issue we examined bacterial killing kinetics at cefditoren concentrations equal to Cmax in the presence of 90% human serum or albumin at physiological concentrations.