Ultrastructural Changes in Contralateral Ves tibulo-ocular Neurons Following Vestibular Neurectomy in the Cat
1991; Taylor & Francis; Volume: 111; Issue: sup477 Linguagem: Inglês
10.3109/00016489109121141
ISSN1651-2251
AutoresRichard R. Gacek, Michael J. Lyon, Joanne Schoonmaker,
Tópico(s)Hearing, Cochlea, Tinnitus, Genetics
ResumoGacek RR, Lyon MJ, Schoonmaker J. Ultrastructural changes in contralateral vestibulo-ocular neurons following vestibular neurectomy in the cat. Acta Otolaryngol (Stockh) 1991; Suppl 477.Twenty contralateral superior vestibular vestibulo-ocular neurons (SVON) from 4 cats were studied morphologically 8 weeks after a right vestibular neurectomy. Nine SVON demonstrated a 35% loss of somal synaptic profiles (SP), normal nuclear and cytoplasmic size, but a slight decrease in organelles responsible for protein synthesis (rough endoplas-mic reticulum and polyribosomes). Eleven SVON showed an 82 % loss of SP, decrease in cell and nuclear size, and significant reduction in rough endoplasmic reticulum (RER) and polyribosomes. These transneuronal SVON changes are presumed to be the result of commissural pathway degeneration caused by the vestibular neurectomy.
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