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Self ‐ Adjuvanting Synthetic Antitumor Vaccines from MUC1 Glycopeptides Conjugated to T ‐ Cell Epitopes from Tetanus Toxoid

2013; Wiley; Volume: 52; Issue: 23 Linguagem: Inglês

10.1002/anie.201300390

1521-3773

Hui Cai, Mei‐Sha Chen, Zhanyi Sun, Yufen Zhao, Horst Kunz, Yanmei Li,

Peptidase Inhibition and Analysis

The T-helper epitope peptide P30 (green in the scheme) from tetanus toxoid was used as the immunostimulant in MUC1 glycopeptide antitumor vaccines and apparently also acts as a built-in adjuvant. P30-conjugated glycopeptide vaccines containing three glycans in the immunodominant motifs PDTRP and GSTAP induced much stronger immune responses and complement dependent cytotoxicity mediated killing of tumor cells when applied in plain PBS solution without complete Freund's adjuvant. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.