The Transcription Factor Pokemon : A New Key Player in Cancer Pathogenesis
2005; American Association for Cancer Research; Volume: 65; Issue: 19 Linguagem: Inglês
10.1158/0008-5472.can-05-1055
ISSN1538-7445
AutoresTakahiro Maeda, Robin M. Hobbs, Pier Paolo Pandolfi,
Tópico(s)RNA modifications and cancer
ResumoAbstract Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARF. Pokemon is overexpressed in multiple human cancers and cells lacking Pokemon are refractory to oncogenic transformation. These findings suggest that Pokemon may offer an effective new target for cancer therapeutics.
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