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Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis

2005; Elsevier BV; Volume: 4; Issue: 6 Linguagem: Inglês

10.1016/s1474-4422(05)70097-1

1474-4465

Mahyar Etminan, Sudeep S. Gill, Ali Samii,

Nuclear Receptors and Signaling

We studied the effect of vitamin C, vitamin E, and beta carotene intake on the risk of Parkinson's disease (PD). We did a systematic review and meta-analysis of observational studies published between 1966 and March 2005 searching MEDLINE, EMBASE, and the Cochrane Library. Eight studies were identified (six case-control, one cohort, and one cross-sectional). We found that dietary intake of vitamin E protects against PD. This protective influence was seen with both moderate intake (relative risk 0.81, 95% CI 0.67-0.98) and high intake (0.78, 0.57-1.06) of vitamin E, although the possible benefit associated with high intake of vitamin E was not significant. The studies did not suggest any protective effects associated with vitamin C or beta carotene. We conclude that dietary vitamin E may have a neuroprotective effect attenuating the risk of PD. These results require confirmation in randomised controlled trials.