Naphthyl Tetronic Acids as Multi‐Target Inhibitors of Bacterial Peptidoglycan Biosynthesis
2007; Wiley; Volume: 2; Issue: 10 Linguagem: Inglês
10.1002/cmdc.200700094
ISSN1860-7187
AutoresTarek S. Mansour, Craig E. Caufield, Beth A. Rasmussen, Rajiv Chopra, Girija Krishnamurthy, Koi Morris, Kristine Svenson, Joel Bard, Claudia Smeltzer, Shaughnessy Naughton, Schuyler Antane, Youjun Yang, Anatoly Severin, Dominick Quagliato, Peter J. Petersen, Guy Singh,
Tópico(s)Antibiotic Resistance in Bacteria
ResumoChemMedChemVolume 2, Issue 10 p. 1414-1417 Communication Naphthyl Tetronic Acids as Multi-Target Inhibitors of Bacterial Peptidoglycan Biosynthesis Tarek S. Mansour Dr., Tarek S. Mansour Dr. mansout@wyeth.com Medicinal Chemistry, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA, Fax: (+1) 845-602-5580Search for more papers by this authorCraig E. Caufield Dr., Craig E. Caufield Dr. Wyeth Research, CN 8000, Princeton, NJ 08543, USASearch for more papers by this authorBeth Rasmussen Dr., Beth Rasmussen Dr. Medicinal Chemistry, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA, Fax: (+1) 845-602-5580Search for more papers by this authorRajiv Chopra Dr., Rajiv Chopra Dr. Wyeth Research, Cambridge, MA 02140, USASearch for more papers by this authorGirija Krishnamurthy Dr., Girija Krishnamurthy Dr. Medicinal Chemistry, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA, Fax: (+1) 845-602-5580Search for more papers by this authorKoi M. Morris, Koi M. Morris Wyeth Research, CN 8000, Princeton, NJ 08543, USASearch for more papers by this authorKristine Svenson, Kristine Svenson Wyeth Research, Cambridge, MA 02140, USASearch for more papers by this authorJoel Bard Dr., Joel Bard Dr. Wyeth Research, Cambridge, MA 02140, USASearch for more papers by this authorClaudia Smeltzer, Claudia Smeltzer Medicinal Chemistry, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA, Fax: (+1) 845-602-5580Search for more papers by this authorShaughnessy Naughton, Shaughnessy Naughton Wyeth Research, CN 8000, Princeton, NJ 08543, USASearch for more papers by this authorSchuyler Antane, Schuyler Antane Wyeth Research, CN 8000, Princeton, NJ 08543, USASearch for more papers by this authorYoujun Yang Dr., Youjun Yang Dr. Medicinal Chemistry, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA, Fax: (+1) 845-602-5580Search for more papers by this authorAnatoly Severin Dr., Anatoly Severin Dr. Medicinal Chemistry, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA, Fax: (+1) 845-602-5580Search for more papers by this authorDominick Quagliato Dr., Dominick Quagliato Dr. Wyeth Research, CN 8000, Princeton, NJ 08543, USASearch for more papers by this authorPeter J. Petersen, Peter J. Petersen Medicinal Chemistry, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA, Fax: (+1) 845-602-5580Search for more papers by this authorGuy Singh Dr., Guy Singh Dr. Medicinal Chemistry, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA, Fax: (+1) 845-602-5580Search for more papers by this author Tarek S. Mansour Dr., Tarek S. Mansour Dr. mansout@wyeth.com Medicinal Chemistry, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA, Fax: (+1) 845-602-5580Search for more papers by this authorCraig E. Caufield Dr., Craig E. Caufield Dr. Wyeth Research, CN 8000, Princeton, NJ 08543, USASearch for more papers by this authorBeth Rasmussen Dr., Beth Rasmussen Dr. Medicinal Chemistry, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA, Fax: (+1) 845-602-5580Search for more papers by this authorRajiv Chopra Dr., Rajiv Chopra Dr. Wyeth Research, Cambridge, MA 02140, USASearch for more papers by this authorGirija Krishnamurthy Dr., Girija Krishnamurthy Dr. Medicinal Chemistry, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA, Fax: (+1) 845-602-5580Search for more papers by this authorKoi M. Morris, Koi M. Morris Wyeth Research, CN 8000, Princeton, NJ 08543, USASearch for more papers by this authorKristine Svenson, Kristine Svenson Wyeth Research, Cambridge, MA 02140, USASearch for more papers by this authorJoel Bard Dr., Joel Bard Dr. Wyeth Research, Cambridge, MA 02140, USASearch for more papers by this authorClaudia Smeltzer, Claudia Smeltzer Medicinal Chemistry, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA, Fax: (+1) 845-602-5580Search for more papers by this authorShaughnessy Naughton, Shaughnessy Naughton Wyeth Research, CN 8000, Princeton, NJ 08543, USASearch for more papers by this authorSchuyler Antane, Schuyler Antane Wyeth Research, CN 8000, Princeton, NJ 08543, USASearch for more papers by this authorYoujun Yang Dr., Youjun Yang Dr. Medicinal Chemistry, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA, Fax: (+1) 845-602-5580Search for more papers by this authorAnatoly Severin Dr., Anatoly Severin Dr. Medicinal Chemistry, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA, Fax: (+1) 845-602-5580Search for more papers by this authorDominick Quagliato Dr., Dominick Quagliato Dr. Wyeth Research, CN 8000, Princeton, NJ 08543, USASearch for more papers by this authorPeter J. Petersen, Peter J. Petersen Medicinal Chemistry, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA, Fax: (+1) 845-602-5580Search for more papers by this authorGuy Singh Dr., Guy Singh Dr. Medicinal Chemistry, Wyeth Research, 401 North Middletown Road, Pearl River, NY 10965, USA, Fax: (+1) 845-602-5580Search for more papers by this author First published: 26 September 2007 https://doi.org/10.1002/cmdc.200700094Citations: 37Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract A pathway screen targeting multiple muramyl peptide synthesis inhibitors identified the naphthyl tetronic acids series. Optimization of this series based on IC50, Kd and MIC values led to potent inhibitors. Compound 5 h was co-crystallized in the active site of E. coli Mur B. Citing Literature Volume2, Issue10October 8, 2007Pages 1414-1417 RelatedInformation
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