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Frequent Estrogen and Progesterone Receptor Immunoreactivity in Renal Angiomyolipomas From Women With Pulmonary Lymphangioleiomyomatosis

2000; Elsevier BV; Volume: 117; Issue: 1 Linguagem: Inglês

10.1378/chest.117.1.25

1931-3543

Helen Logginidou, Xiang Ao, Irma H. Russo, Elizabeth P. Henske,

Renal cell carcinoma treatment

Objective To determine whether renal angiomyolipomasfrom women with pulmonary lymphangioleiomyomatosis (LAM) expressestrogen receptor (ER) and progesterone receptor (PR). Design Retrospective study of archival tissue. Patients Twelve women with LAM and angiomyolipomas. Setting Fox Chase Cancer Center. Interventions ER and PR expression was studied usingimmunohistochemistry. The hormonal status of the patients at the timeof resection of the angiomyolipoma was determined. Results Ten of the angiomyolipomas had ER immunoreactivity(83%), and all 12 had PR immunoreactivity (100%). The ER and PRpositivity was in the smooth muscle component of the angiomyolipomasonly. For five women, pulmonary LAM specimens were also available; twowere ER positive (40%), and all five were PR positive (100%). Allfour angiomyolipomas from women receiving progesterone therapy were ERand PR positive. One tumor from a woman receiving tamoxifen was ERnegative and strongly PR positive. One woman was pregnant; her tumorwas ER and PR positive. Conclusions ER and PRexpression is frequent in renal angiomyolipoma cells from women withLAM. PR was more consistently present than ER in angiomyolipomas and inLAM. Our data suggest that angiomyolipoma growth could be affected byhormonal factors. If the growth of LAM-associated angiomyolipomas slowsduring hormonal therapy, there are two potential implications for LAMpatients: first, angiomyolipoma size could serve as a measurableindication of response to hormonal therapy; and second, surgicalremoval of angiomyolipomas might be avoided in somecases. To determine whether renal angiomyolipomasfrom women with pulmonary lymphangioleiomyomatosis (LAM) expressestrogen receptor (ER) and progesterone receptor (PR). Retrospective study of archival tissue. Twelve women with LAM and angiomyolipomas. Fox Chase Cancer Center. ER and PR expression was studied usingimmunohistochemistry. The hormonal status of the patients at the timeof resection of the angiomyolipoma was determined. Ten of the angiomyolipomas had ER immunoreactivity(83%), and all 12 had PR immunoreactivity (100%). The ER and PRpositivity was in the smooth muscle component of the angiomyolipomasonly. For five women, pulmonary LAM specimens were also available; twowere ER positive (40%), and all five were PR positive (100%). Allfour angiomyolipomas from women receiving progesterone therapy were ERand PR positive. One tumor from a woman receiving tamoxifen was ERnegative and strongly PR positive. One woman was pregnant; her tumorwas ER and PR positive. ER and PRexpression is frequent in renal angiomyolipoma cells from women withLAM. PR was more consistently present than ER in angiomyolipomas and inLAM. Our data suggest that angiomyolipoma growth could be affected byhormonal factors. If the growth of LAM-associated angiomyolipomas slowsduring hormonal therapy, there are two potential implications for LAMpatients: first, angiomyolipoma size could serve as a measurableindication of response to hormonal therapy; and second, surgicalremoval of angiomyolipomas might be avoided in somecases.