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BRAIN FUNCTION IN OBSTRUCTIVE SLEEP APNEA: RESULTS FROM THE BRAIN RESOURCE INTERNATIONAL DATABASE

2006; Imperial College Press; Volume: 05; Issue: 01 Linguagem: Inglês

10.1142/s0219635206001033

1757-448X

Keith Wong, Ronald R. Grunstein, Delwyn J. Bartlett, Evian Gordon,

Sleep and Wakefulness Research

Journal of Integrative NeuroscienceVol. 05, No. 01, pp. 111-121 (2006) No AccessBRAIN FUNCTION IN OBSTRUCTIVE SLEEP APNEA: RESULTS FROM THE BRAIN RESOURCE INTERNATIONAL DATABASEKEITH K. H. WONG, RONALD R. GRUNSTEIN, DELWYN J. BARTLETT, and EVIAN GORDONKEITH K. H. WONGSleep and Circadian Research Group, Woolcock Institute of Medical Research, University of Sydney, Camperdown, NSW 2050, AustraliaCorresponding author., RONALD R. GRUNSTEINSleep and Circadian Research Group, Woolcock Institute of Medical Research, University of Sydney, Camperdown, NSW 2050, Australia, DELWYN J. BARTLETTSleep and Circadian Research Group, Woolcock Institute of Medical Research, University of Sydney, Camperdown, NSW 2050, Australia, and EVIAN GORDONIntegrative Neuroscience, Brain Dynamics Center, University of Sydney and Westmead Hospital, NSW 2145, AustraliaDiscipline of Psychological Medicine, University of Sydney, NSW 2006, AustraliaThe Brain Resource Company and the Brain Resource International Database, Ultimo, NSW 2007, Australiahttps://doi.org/10.1142/S0219635206001033Cited by:23 PreviousNext AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail AbstractObstructive sleep apnea (OSA) is expected to impair vigilance and executive functioning, owing to the sensitivity of the prefrontal cortex to the effects of sleep fragmentation and intermittent hypoxia. Studies examining the pattern of cognitive dysfunction show variable results, with the heterogeneity in part due to small sample sizes in current studies and little consistency of the tests used. We examined a group of fifty subjects from the Brain Resource International Database (BRID), predicted to have OSA on the basis of the Multivariable Apnea Prediction Index, and compared them with 200 matched controls. On electrophysiological tests, the OSA group showed reduced eyes closed alpha power, increased auditory oddball N100 and P200 amplitude, but reduced N200 and P300 amplitude. The latency to P300 was not significantly different between groups, but latencies to N200 and P200 were prolonged in the OSA group. Performance testing of the executive function found that verbal interference and the switching of attention were impaired in the OSA group. 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