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MGUS and Smoldering Multiple Myeloma: Update on Pathogenesis, Natural History, and Management

2005; American Society of Hematology; Volume: 2005; Issue: 1 Linguagem: Inglês

10.1182/asheducation-2005.1.340

1520-4391

S. Vincent Rajkumar,

Protein Degradation and Inhibitors

Abstract Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are asymptomatic, pre-malignant disorders characterized by monoclonal plasma cell proliferation in the bone marrow and absence of end-organ damage. Recent advances in the pathogenesis, natural history, and prognosis of MGUS and SMM are reviewed. A new risk stratification system to determine the prognosis of MGUS using the size and type of M protein, and the serum free light chain assay is discussed.