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Design of Novel BSA/Hyaluronic Acid Nanodispersions for Transdermal Pharma Purposes

2014; American Chemical Society; Volume: 11; Issue: 5 Linguagem: Inglês

10.1021/mp400657g

1543-8392

Madalena Martins, Nuno G. Azóia, Ulyana Shimanovich, Teresa Matamá, Andreia C. Gomes, Carla Silva, Artur Cavaco‐Paulo,

Advanced Drug Delivery Systems

A novel transdermal hyaluronic acid (HA) conjugated with bovine serum albumin (BSA) was developed in the form of solid-in-oil (S/O) nanodispersion (129.7 nm mean diameter). Ex vivo skin penetration analysis by fluorescence and confocal observation of histological skin sections revealed the ability of BSA/HA nanodispersions to cross the stratum corneum and penetrate into the dermis. Furthermore, no significant toxicity was found in fibroblast and keratinocyte cells in vitro. These results proved the potential of the developed nanodispersion for transdermal delivery of hyaluronic acid constituting a high value to biopharmaceutical and cosmetics industries.