Ischemia/reperfusion injury in microvascular surgery
2000; Wiley; Volume: 22; Issue: 7 Linguagem: Inglês
10.1002/1097-0347(200010)22
ISSN1097-0347
AutoresWilliam R. Carroll, Ramon M. Esclamado,
Tópico(s)Organ Transplantation Techniques and Outcomes
ResumoIschemia/reperfusion injury is often the final and irreversible factor causing flap failure in microvascular surgery for head and neck defects. This paper begins with a detailed review of flap physiology and ischemia/reperfusion injury at the cellular level. Subsequently, the pharmacotherapeutic agents used clinically and experimentally to avoid or reverse ischemia/reperfusion injury are discussed. The goal of this review is to provide a framework for understanding the expanding body of literature relevant to ischemia/reperfusion injury in microvascular surgery. © 2000 John Wiley & Sons, Inc. Head Neck 22: 700–713, 2000.
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