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Antineoplastic Agents 430. Isolation and Structure of Cribrostatins 3, 4, and 5 from the Republic of Maldives Cribrochalina Species

2000; American Chemical Society; Volume: 63; Issue: 6 Linguagem: Inglês

10.1021/np990618q

1520-6025

George R. Pettit, John Knight, Jeremiah C. Collins, Delbert L. Herald, Robin K. Pettit, Michael R. Boyd, Victor G. Young,

Microbial Natural Products and Biosynthesis

Continued investigation of cancer-cell growth-inhibitory constituents of the blue marine sponge Cribrochalina sp. has led to discovery of cribrostatins 3 (4a), 4 (5), and 5 (4b) in 10-5 to 10-7 % of the wet weight. The structure of cribrostatin 3 (4a) was determined by results of high field (500 MHz) 1H and 13C NMR and HRMS interpretations. The same general approach to the structures of cribrostatins 4 (5) and 5 (4b) was completed by X-ray crystal structure determinations. Cribrostatins 3, 4, and 5 provided significant cancer cell line inhibitory activities. Cribrostatins 1 and 22 and the newly isolated cribrostatins 3−5 displayed antibacterial and/or antifungal activities.