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Effect of short- and long-duration spaceflight on QTc intervals in healthy astronauts

2003; Elsevier BV; Volume: 91; Issue: 4 Linguagem: Inglês

10.1016/s0002-9149(02)03259-9

1879-1913

Dominick S. D’Aunno, Anne H. Dougherty, Heidi F. DeBlock, Janice V. Meck,

Heart Rate Variability and Autonomic Control

The human cardiovascular system undergoes profound changes when exposed to spaceflight, including cardiac rhythm disturbances during long-term missions. 1 Fritsch-Yelle J.M. Leuenberger U.A. D'Aunno D.S. Rossum A.C. Brown T.E. Wood M.L. Josephson M.E. Goldberger A.L. An episode of ventricular tachycardia during long-duration spaceflight. Am J Cardiol. 1998; 81: 1391-1392 Abstract Full Text Full Text PDF PubMed Scopus (74) Google Scholar , 2 Pestov ID, Gerathewohl SJ. Weightlessness. In: Calvin M, Gazenko OK, eds. Foundations of Space Biology and Medicine. NASA SP-374, Washington, DC: US Government Printing Office, 1995:305–354 Google Scholar , 3 Smith R.F. Stanton K. Stoop D. et al. Vectorcardiographic changes during extended space flight (MO93) observations at rest and during exercise. in: Johnston R.S. Dietlein L.F. Biomedical Results from Skylab. National Aeronautics and Space Administration, Washington, DC1977: 339-350 Google Scholar , 4 Hoffler G.W. Wolthuis R.A. Johnson R.L. Apollo space crew cardiovascular evaluations. Aerosp Med. 1974; 45: 807-820 PubMed Google Scholar , 5 Grigoriev AI, Egorov AD. Long-term flight. In: Nicgossian A, Mohler SR, Gazenko OG, Grigoriev AI, eds. Space Biology and Medicine: Joint U.S./Russian. Reston, VA: American Institute of Aeronautics and Astronautics, 1996:485–532 Google Scholar Underlying spaceflight-induced alterations in cardiovascular autonomic regulation may adversely influence cardiac repolarization and thus precipitate these rhythm disturbances. 6 Fritsch J.M. Charles J.B. Bennett B.S. Jones M.M. Eckberg D.L. Short-duration spaceflight impairs human carotid baroreceptor-cardiac reflex responses. J Appl Physiol. 1992; 73: 664-671 PubMed Google Scholar , 7 Fritsch-Yelle J.M. Charles J.B. Jones M.M. Beightol L.A. Eckberg D.L. Spaceflight alters autonomic regulation of arterial pressure in humans. J Appl Physiol. 1994; 77: 1776-1783 PubMed Google Scholar , 8 Fritsch-Yelle J.M. Whitson P.A. Bondar R.L. Brown T.E. Subnormal norepinephrine release relates to presyncope in astronauts after spaceflight. J Appl Physiol. 1996; 81: 2134-2141 PubMed Google Scholar Therefore, we analyzed electrocardiograms or Holter monitor tracings obtained from astronauts who experienced short- and long-duration space missions. Our findings reveal striking differences in cardiac conduction and repolarization between short- and long-duration spaceflight.