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Identification of deletion mutations and three new genes at the familial polyposis locus

1991; Cell Press; Volume: 66; Issue: 3 Linguagem: Inglês

10.1016/0092-8674(81)90022-2

1097-4172

Geoff Joslyn, M. Carlson, Andrew Thliveris, Hans Albertsen, Lawrence M. Gelbert, Wade S. Samowitz, Joanna Groden, Jeff Stevens, Lisa Spirio, Margaret Robertson, Leslie S. Sargeant, K. Krapcho, Erika M. Wolff, Randall W. Burt, Jaime Hughes, Janet A. Warrington, John D. McPherson, John J. Wasmuth, Denis Le Paslier, Hadi Abderrahim, Daniel Cohen, Mark Leppert, R. White,

Cancer Genomics and Diagnostics

Small (100-260 kb), nested deletions were characterized in DNA from two unrelated patients with familial adenomatous polyposis coli (APC). Three candidate genes located within the deleted region were ascertained and a previous candidate gene, MCC, was shown to be located outside the deleted region. One of the new genes contained sequence identical to SRP19, the gene coding for the 19 kd component of the ribosomal signal recognition particle. The second, provisionally designated DP1 (deleted in polyposis 1), was found to be transcribed in the same orientation as MCC. Two other cDNAs, DP2 and DP3, were found to overlap, forming a single gene, DP2.5, that is transcribed in the same orientation as SRP19.