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BIBTEX RIS

Hard palate hyperpigmentation secondary to chronic chloroquine therapy: report of five cases

2013; Wiley; Volume: 40; Issue: 9 Linguagem: Inglês

10.1111/cup.12182

1600-0560

Bruno Augusto Benevenuto de Andrade, Felipe Paiva Fonseca, Fábio Ramôa Pires, Ana Terezinha Marques Mesquita, Saulo Gabriel Moreira Falci, Alan Roger Santos‐Silva, Pablo Agustín Vargas, Jacks Jorge, Oslei Paes de Almeida,

Leprosy Research and Treatment

Antimalarials are commonly prescribed in medical practice for conditions such as rheumatoid arthritis, lupus erythematosus, as well as malaria. They are generally well-tolerated, but side effects, although infrequent, are well known. The antimalarial chloroquine diphosphate may be associated with a bluish-gray to black hyperpigmentation of the oral mucosa, mainly on the hard palate. In this report we described five additional cases of palate hyperpigmentation related to the chronic use of chloroquine diphosphate. Professionals must be aware of the adverse effects of antimalarials as chloroquine diphosphate in order to make the correct diagnosis and appropriate management of the patient. Early diagnosis of oral pigmentation by antimalarials may be of great relevance, because it might be an early sign of ocular involvement, and therefore it may be helpful to prevent further complications of antimalarial therapy for the patient.