T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo
2001; Oxford University Press; Volume: 13; Issue: 6 Linguagem: Inglês
10.1093/intimm/13.6.763
ISSN1460-2377
AutoresLaëtitia Vivien, Christophe Benoist, Diane Mathis,
Tópico(s)Immunotherapy and Immune Responses
ResumoThe role of IL-4, -6 and -7 in the survival of T lymphocytes was studied in vivo. The decay of polyclonal populations of CD4+ and CD8+ T cells was monitored in thymectomized anti-cytokine receptor mAb-treated and/or cytokine-deficient mice. The lack of IL-4 or -6 did not have any detectable effect on T cell survival, but IL-7 played an important role in the survival of the naive T cell compartment, especially of naive CD4+ T cells.
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