Identification and characterization of a novel HLA‐DRB1 allele, DRB1*0830*
2005; Wiley; Volume: 66; Issue: 2 Linguagem: Inglês
10.1111/j.1399-0039.2005.00431.x
ISSN1399-0039
AutoresBerthold Hoppe, Guido Heymann, H. Kiesewetter, A. Salama,
Tópico(s)Immunotherapy and Immune Responses
ResumoHere, we report on the identification and characterization of a novel human leukocyte antigen (HLA) DRB1 allele, DRB1*0830. This allele was identified in a candidate for hematopoietic stem cell donation. While the DNA sequence of HLA-DRB1*0830 most closely matches to DRB1*080202, its amino acid sequence resembles DRB1*080202 and DRB1*0813. Due to a substitution at nucleotide position 286 HLA-typing using sequence-specific oligonucleotide hybridization or amplification using sequence-specific primers gave inconclusive results. Allele-specific DNA sequencing confirmed a 286 T-->A substitution resulting in Phe67Ile.
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