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Chagas Disease Is an Independent Risk Factor for Stroke

2005; Lippincott Williams & Wilkins; Volume: 36; Issue: 9 Linguagem: Inglês

10.1161/01.str.0000177866.13451.e4

1524-4628

Jamary Oliveira‐Filho, Leila C. Viana, Rodrigo M. Vieira-de-Melo, Frederico Faiçal, Jorge Andion Torreão, Flávio Augusto Guerreiro Aragão de Villar, Francisco José Farias Borges dos Reis,

Lysosomal Storage Disorders Research

Background and Purpose— Chagas disease (CD) is frequently associated with cardioembolic stroke in South America. Our objective was to identify the predictors of stroke in a region where CD is endemic. Methods— We screened 305 consecutive cardiopathy patients. Significant predictors of stroke in univariable analyses were included in a multivariable model. Results— Stroke was more frequent in CD (15.0%) compared with other cardiopathies (6.3%; P =0.015). Other predictors of stroke in univariable analyses were previous diabetes or cardioversion and use of amiodarone, antiplatelet agents, and warfarin. In multivariable analysis, remaining predictors of stroke were CD (odds ratio [OR], 1.09; 95% CI, 1.02 to 1.17), cardioversion (OR, 1.07; 95% CI, 1.02 to 1.13), and diabetes (OR, 1.12; 95% CI, 1.01 to 1.24). Conclusions— In conclusion, CD is a risk factor for stroke, independent of systolic dysfunction or presence of cardiac arrhythmias.