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Experimental nodel of C6 brain tumors in athymic rats

2008; Thieme Medical Publishers (Germany); Volume: 66; Issue: 2a Linguagem: Inglês

10.1590/s0004-282x2008000200019

1678-4227

Flávio Key Miura, Maria José Ferreira Alves, Mussya Cisotto Rocha, Roseli S. Silva, Sueli Mieko Oba‐Shinjo, Miyuki Uno, Christian Colin, Mari Cleide Sogayar, Suely Kazue Nagahashi Marie,

Neuroinflammation and Neurodegeneration Mechanisms

Malignant brain tumor experimental models tend to employ cells that are immunologically compatible with the receptor animal. In this study, we have proposed an experimental model of encephalic tumor development by injecting C6 cells into athymic Rowett rats, aiming at reaching a model which more closely resembles to the human glioma tumor. In our model, we observed micro-infiltration of tumor cell clusters in the vicinity of the main tumor mass, and of more distal isolated tumor cells immersed in normal encephalic parenchyma. This degree of infiltration is superior to that usually observed in other C6 models.