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Presence of Human Immunodeficiency Virus (HIV) Type 1 Subtype A Infection in a New York Community with High HIV Prevalence: A Sentinel Site for Monitoring HIV Genetic Diversity in North America

1997; Oxford University Press; Volume: 176; Issue: 6 Linguagem: Inglês

10.1086/517343

1537-6613

Kathleen L. Irwin, Chou‐Pong Pau, Davis Lupo, Danuta Pienazek, Chi‐Cheng Luo, Noemí Olivo, Mark A. Rayfield, Dale J. Hu, Jonathan Weber, Richard Respess, Robert Janssen, Patrick Minor, Jerome Ernst, the Centers for Disease Control,

Diabetes and associated disorders

To determine whether US residents are infected with subtypes of human immunodeficiency virus (HIV) type 1 other than subtype B (Western), the predominant North American subtype with a unique GPGR genetic sequence in the V3 loop, viruses from 22 HIV-infected adults were serotyped and subtyped. Twenty patients had subtype B (Western), of whom 15 had serotype B (Western), 3 had serotype A/C, 1 had serotype B (Thai), and 1 had a nontypeable serotype. Two had subtype A, both serotype A/C. Both subtype A-infected patients, only 1 of whom had been outside the United States, reported sex with persons traveling abroad, suggesting possible acquisition in the United States. Because US residents are infected with non-subtype B (Western) strains, US surveillance for HIV-1 diversity is needed to elucidate subtype-specific transmission patterns and pathogenesis and to guide evaluation and development of HIV diagnostic tests and vaccines.