Effects of potential inhibitors on Brugia pahangi in vitro : macrofilaricidal action and inhibition of microfilarial production
1989; Cambridge University Press; Volume: 99; Issue: 3 Linguagem: Inglês
10.1017/s0031182000059138
ISSN1469-8161
AutoresGuy C. Barker, Julian G. Mercer, James A. Svoboda, M. J. Thompson, Hannah Rees, R. E. Howells,
Tópico(s)Plant tissue culture and regeneration
ResumoSummary A series of compounds that apparently disrupt hormonally regulated processes in insects have been examined for effects on the viability and microfilarial production of adult Brugia pahangi cultured in vitro . The azasteroids, 25-azacoprostane and 25-azacholestane, inhibited the production of microfilariae at 5 ppm, the former also exhibiting macrofilaricidal activity at this concentration. The brassinosteroids examined inhibited microfilarial production at 5 ppm but did not affect worm viability. Azadirachtin also proved to be a significant inhibitor of microfilarial release without effect on worm motility or viability. Of all the compounds tested, the non-steroidal amines appeared to be the most promising as potential filaricides, several of them proving to be macrofilaricidal at 1 ppm and affecting microfilarial production at even lower concentrations.
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