Portal de Periódicos da CAPES

Effects of functional group position on spatial representations of aliphatic odorants in the rat olfactory bulb

2005; Wiley; Volume: 483; Issue: 2 Linguagem: Inglês

10.1002/cne.20415

1096-9861

Brett A. Johnson, Haleh Farahbod, Sepideh Saber, Michael Leon,

Neurobiology and Insect Physiology Research

Journal of Comparative NeurologyVolume 483, Issue 2 p. 192-204 Article Effects of functional group position on spatial representations of aliphatic odorants in the rat olfactory bulb Brett A. Johnson, Corresponding Author Brett A. Johnson bajohnso@uci.edu Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697-4550Department of Neurobiology and Behavior, 2205 McGaugh Hall, University of California, Irvine, Irvine, California 92697-4550Search for more papers by this authorHaleh Farahbod, Haleh Farahbod Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697-4550Search for more papers by this authorSepideh Saber, Sepideh Saber Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697-4550Search for more papers by this authorMichael Leon, Michael Leon Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697-4550Search for more papers by this author Brett A. Johnson, Corresponding Author Brett A. Johnson bajohnso@uci.edu Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697-4550Department of Neurobiology and Behavior, 2205 McGaugh Hall, University of California, Irvine, Irvine, California 92697-4550Search for more papers by this authorHaleh Farahbod, Haleh Farahbod Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697-4550Search for more papers by this authorSepideh Saber, Sepideh Saber Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697-4550Search for more papers by this authorMichael Leon, Michael Leon Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697-4550Search for more papers by this author First published: 27 January 2005 https://doi.org/10.1002/cne.20415Citations: 32Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Principles of olfactory coding can be clarified by studying the olfactory bulb activity patterns that are evoked by odorants differing systematically in chemical structure. In the present study, we used series of aliphatic esters, ketones, and alcohols (27 odorants total) to determine the effects of functional group position on glomerular-layer activity patterns. These patterns were measured as uptake of [14C]2-deoxyglucose and were mapped into standardized data matrices for statistical comparison across different rats. The magnitude of the effect of position differed greatly for the different functional groups. For ketones, there was little or no effect of position on evoked patterns. For esters, uptake in individual glomerular modules increased, whereas uptake in others decreased with changing group position, yet the overall patterns remained similar. For alcohols, group position had a profound effect on evoked activity patterns. For example, moving the hydroxyl group in either heptanol or nonanol from the first to the fourth carbon changed the activity patterns so greatly that the major areas of response did not overlap. Within every functional group series, however, responses were globally chemotopic, such that pairs of odorants with the smallest difference in functional group position evoked the most similar patterns. These results help to define further the specificities of glomeruli within previously described glomerular modules, and they show that functional group position can be an important feature in encoding an odorant molecule. J. Comp. Neurol. 483:192–204, 2005. © 2005 Wiley-Liss, Inc. Citing Literature Supporting Information Filename Description jwsCNEv483.2.192.fig1.psd33.3 MB Supplementary Figure 1:Dorsal-centered versions of the patterns evoked by alcohol odorants that were shown in Figure 1. These charts represent data matrices averaged across multiple rats and are presented as rolled-out maps of the glomerular layer as if a cut had been made ventrally running anterior to posterior. jwsCNEv483.2.192.fig2.psd43.1 MB Supplementary Figure 2:Dorsal-centered versions of the patterns evoked by esters odorants that were shown in Figure 4. The charts are oriented as in Supplementary Figure 1. jwsCNEv483.2.192.fig3.psd15.8 MB Supplementary Figure 3:Dorsal-centered versions of the patterns evoked by ketone odorants that were shown in Figure 6. The charts are oriented as in Supplementary Figure 1. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume483, Issue27 March 2005Pages 192-204 RelatedInformation