Reliability and validity of the International Cooperative Ataxia Rating Scale: A study in 156 spinocerebellar ataxia patients
2006; Wiley; Volume: 21; Issue: 5 Linguagem: Inglês
10.1002/mds.20781
ISSN1531-8257
AutoresTanja Schmitz‐Hübsch, Sophie Tézenas du Montcel, László Balikó, Sylvia Boesch, Sara Bonato, Roberto Fancellu, Paola Giunti, Christoph Globas, Jun‐Suk Kang, Berry Kremer, Caterina Mariotti, Béla Melegh, Maria Rakowicz, Rafał Rola, Silvia Romano, Lüdger Schöls, Sandra Szymanski, Bart P.C. van de Warrenburg, Elżbieta Zdzienicka, Alexandra Dürr, Thomas Klockgether,
Tópico(s)Neurological disorders and treatments
ResumoMovement DisordersVolume 21, Issue 5 p. 699-704 Brief Report Reliability and validity of the International Cooperative Ataxia Rating Scale: A study in 156 spinocerebellar ataxia patients Tanja Schmitz-Hübsch MD, Corresponding Author Tanja Schmitz-Hübsch MD tanja.schmitz-huebsch@ukb.unibonn.de Department of Neurology, University Hospital of Bonn, Bonn, GermanyDepartment of Neurology, University Hospital of Bonn, Sigmund-Freud-Strasse 25, D-53105 Bonn, GermanySearch for more papers by this authorSophie Tezenas du Montcel MD, PhD, Sophie Tezenas du Montcel MD, PhD Department of Biostatistics and Medical Informatics, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux Paris, France Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie, Paris, FranceSearch for more papers by this authorLaszlo Baliko MD, Laszlo Baliko MD Department of Neurology and Stroke, County Hospital, Veszprém, HungarySearch for more papers by this authorSylvia Boesch MD, Sylvia Boesch MD Department of Neurology, University of Innsbruck, Innsbruck, AustriaSearch for more papers by this authorSara Bonato MD, Sara Bonato MD Department of Neurology, Hôpital Erasme, University of Brussels, Brussels, BelgiumSearch for more papers by this authorRoberto Fancellu MD, Roberto Fancellu MD Department of Biochemistry and Genetics, Istituto Nazionale Neurologico C. Besta, Milan, ItalySearch for more papers by this authorPaola Giunti MD, Paola Giunti MD Institute of Neurology, London, United KingdomSearch for more papers by this authorChristoph Globas MD, Christoph Globas MD Department of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, GermanySearch for more papers by this authorJun-Suk Kang MD, Jun-Suk Kang MD Department of Neurology, University of Frankfurt, Frankfurt, GermanySearch for more papers by this authorBerry Kremer MD,, Berry Kremer MD, Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The NetherlandsSearch for more papers by this authorCaterina Mariotti MD, Caterina Mariotti MD Department of Biochemistry and Genetics, Istituto Nazionale Neurologico C. Besta, Milan, ItalySearch for more papers by this authorBela Melegh MD, PhD, Bela Melegh MD, PhD Department of Genetics, University of Pecs, Pecs, HungarySearch for more papers by this authorMaryla Rakowicz MD, Maryla Rakowicz MD Institute of Psychiatry and Neurology, Warsaw, PolandSearch for more papers by this authorRafal Rola MD, Rafal Rola MD Institute of Psychiatry and Neurology, Warsaw, PolandSearch for more papers by this authorSylvie Romano MD, Sylvie Romano MD Department of Biochemistry and Genetics, Istituto Nazionale Neurologico C. Besta, Milan, ItalySearch for more papers by this authorLodger Schöls MD, Lodger Schöls MD Department of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, GermanySearch for more papers by this authorSandra Szymanski MD, Sandra Szymanski MD Department of Neurology, St. Josef Hospital, University Hospital, Bochum, GermanySearch for more papers by this authorBart P.C. van de Warrenburg MD, Bart P.C. van de Warrenburg MD Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The NetherlandsSearch for more papers by this authorElzbieta Zdzienicka MD, Elzbieta Zdzienicka MD Institute of Psychiatry and Neurology, Warsaw, PolandSearch for more papers by this authorAlexandra Dürr MD, Alexandra Dürr MD INSERM U679 and Department of Genetics, Cytogenetics and Embryology, Hôpital de la Pitié-Salpêtrière, Paris, FranceSearch for more papers by this authorThomas Klockgether MD, Thomas Klockgether MD Department of Neurology, University Hospital of Bonn, Bonn, GermanySearch for more papers by this author Tanja Schmitz-Hübsch MD, Corresponding Author Tanja Schmitz-Hübsch MD tanja.schmitz-huebsch@ukb.unibonn.de Department of Neurology, University Hospital of Bonn, Bonn, GermanyDepartment of Neurology, University Hospital of Bonn, Sigmund-Freud-Strasse 25, D-53105 Bonn, GermanySearch for more papers by this authorSophie Tezenas du Montcel MD, PhD, Sophie Tezenas du Montcel MD, PhD Department of Biostatistics and Medical Informatics, Hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux Paris, France Modeling in Clinical Research, EA 3974, University Pierre et Marie Curie, Paris, FranceSearch for more papers by this authorLaszlo Baliko MD, Laszlo Baliko MD Department of Neurology and Stroke, County Hospital, Veszprém, HungarySearch for more papers by this authorSylvia Boesch MD, Sylvia Boesch MD Department of Neurology, University of Innsbruck, Innsbruck, AustriaSearch for more papers by this authorSara Bonato MD, Sara Bonato MD Department of Neurology, Hôpital Erasme, University of Brussels, Brussels, BelgiumSearch for more papers by this authorRoberto Fancellu MD, Roberto Fancellu MD Department of Biochemistry and Genetics, Istituto Nazionale Neurologico C. Besta, Milan, ItalySearch for more papers by this authorPaola Giunti MD, Paola Giunti MD Institute of Neurology, London, United KingdomSearch for more papers by this authorChristoph Globas MD, Christoph Globas MD Department of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, GermanySearch for more papers by this authorJun-Suk Kang MD, Jun-Suk Kang MD Department of Neurology, University of Frankfurt, Frankfurt, GermanySearch for more papers by this authorBerry Kremer MD,, Berry Kremer MD, Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The NetherlandsSearch for more papers by this authorCaterina Mariotti MD, Caterina Mariotti MD Department of Biochemistry and Genetics, Istituto Nazionale Neurologico C. Besta, Milan, ItalySearch for more papers by this authorBela Melegh MD, PhD, Bela Melegh MD, PhD Department of Genetics, University of Pecs, Pecs, HungarySearch for more papers by this authorMaryla Rakowicz MD, Maryla Rakowicz MD Institute of Psychiatry and Neurology, Warsaw, PolandSearch for more papers by this authorRafal Rola MD, Rafal Rola MD Institute of Psychiatry and Neurology, Warsaw, PolandSearch for more papers by this authorSylvie Romano MD, Sylvie Romano MD Department of Biochemistry and Genetics, Istituto Nazionale Neurologico C. Besta, Milan, ItalySearch for more papers by this authorLodger Schöls MD, Lodger Schöls MD Department of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, GermanySearch for more papers by this authorSandra Szymanski MD, Sandra Szymanski MD Department of Neurology, St. Josef Hospital, University Hospital, Bochum, GermanySearch for more papers by this authorBart P.C. van de Warrenburg MD, Bart P.C. van de Warrenburg MD Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The NetherlandsSearch for more papers by this authorElzbieta Zdzienicka MD, Elzbieta Zdzienicka MD Institute of Psychiatry and Neurology, Warsaw, PolandSearch for more papers by this authorAlexandra Dürr MD, Alexandra Dürr MD INSERM U679 and Department of Genetics, Cytogenetics and Embryology, Hôpital de la Pitié-Salpêtrière, Paris, FranceSearch for more papers by this authorThomas Klockgether MD, Thomas Klockgether MD Department of Neurology, University Hospital of Bonn, Bonn, GermanySearch for more papers by this author First published: 31 January 2006 https://doi.org/10.1002/mds.20781Citations: 107Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract To evaluate the efficacy of treatments in spinocerebellar ataxias (SCAs), appropriate clinical scales are required. This study evaluated metric properties of the International Cooperative Ataxia Rating Scale (ICARS) in 156 SCA patients and 8 controls. ICARS was found to be a reliable scale satisfying accepted criteria for interrater reliability, test–retest reliability, and internal consistency. Although validity testing was limited, we found evidence of validity of ICARS when ataxia disease stages and Barthel index were used as external criteria. On the other hand, our study revealed two major problems associated with the use of ICARS. First, the redundant and overlapping nature of several items gave rise to a considerable number of contradictory ratings. Second, a factorial analysis showed that the rating results were determined by four different factors that did not coincide with the ICARS subscales, thus questioning the justification of ICARS subscore analysis in clinical trials. © 2006 Movement Disorder Society Citing Literature Volume21, Issue5May 2006Pages 699-704 RelatedInformation
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