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BIBTEX RIS

Charcot Neuroarthropathy After Simultaneous Pancreas-Kidney Transplant

2012; Wolters Kluwer; Volume: 94; Issue: 6 Linguagem: Inglês

10.1097/tp.0b013e31825cadbb

1534-6080

Érika Bevilaqua Rangel, João Roberto de Sá, Samirah Abreu Gomes, Aluízio Barbosa Carvalho, Cláudio S. Melaragno, Adriano Miziara Gonzalez, Marcelo Moura Linhares, José Osmar Medina Pestana,

Neurological and metabolic disorders

Background Immunosuppressive regimen is associated with several metabolic adverse effects. Bone loss and fractures are frequent after transplantation and involve multifactorial mechanisms. Methods A retrospective analysis of 130 patients submitted to simultaneous pancreas-kidney transplantation (SPKT) and an identification of risk factors involved in de novo Charcot neuroarthropathy by multivariate analysis were used; P 78 mg/kg) and not adjusted to body weight were associated with Charcot neuroarthropathy (P=0.001 and P<0.0001, respectively). Age, gender, race, time on dialysis, time of diabetes history, and posttransplantation hyperparathyroidism were not related to Charcot neuroarthropathy after SPKT. Conclusions Glucocorticoids are the main risk factors for de novo Charcot neuroarthropathy after SPKT. Protocols including glucocorticoid avoidance or minimization should be considered.