Activation of Nuclear Factor-κB in Acinar Cells Increases the Severity of Pancreatitis in Mice
2012; Elsevier BV; Volume: 144; Issue: 1 Linguagem: Inglês
10.1053/j.gastro.2012.09.059
ISSN1528-0012
AutoresHaojie Huang, Yan Liu, Jarosław Daniluk, Sebastian Gaiser, Jun Chu, Huamin Wang, Zhao‐Shen Li, Craig D. Logsdon, Baoan Ji,
Tópico(s)Diabetes and associated disorders
ResumoNuclear factor-κB (NF-κB) is activated during early stages of pancreatitis. This transcription factor regulates genes that control many cell activities, including inflammation and survival. There is evidence that activation of NF-κB protects against pancreatitis, and, in other cases, that it promotes this disease. We compared the effects of NF-κB in different mouse models of pancreatitis to understand these complications.
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