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Pretreatment with montelukast blocks NSAID-induced urticaria and angioedema

2001; Elsevier BV; Volume: 108; Issue: 6 Linguagem: Inglês

10.1067/mai.2001.120275

1097-6825

Carlos Pérez, Mario Sánchez‐Borges, Eric Capriles,

Inflammatory mediators and NSAID effects

importance of screening for cross-reactivity with a molecule in the same pharmaceutical class when a type I hypersensitivity mechanism has been demonstrated for one molecule of this class in order to use a molecule that has similar pharmacologic properties but does not share its immunological cross-reactivity.Only when results of tests (skin tests, LHRT) with the drug that caused the reaction are positive do negative tests with the related drugs have a strong negative value and indicate that they can be used safely, as has been previously demonstrated for muscle relaxants. 7 The mechanism by which this patient became sensitized to granisetron, given that she had never received it, remains unknown.This was certainly the first time that the patient had received this drug, which leaves us in the dark about the origin of sensitization.The absence of prior contact with the drug, usually required for sensitization, occurs more frequently than is realized.It is well known for muscle relaxants: 30% of patients who have an anaphylactic reaction to muscle relaxants are undergoing general anesthesia for the first time in their life. 7