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Bradykinin activation of fibroblasts of the rat subcutaneous tissue triggers the release of ATP and P2 purinoceptors activation

2012; Elsevier BV; Volume: 16; Issue: 2 Linguagem: Inglês

10.1016/j.jbmt.2012.01.069

1532-9283

Ana Rita Pinheiro, Mariana Certal, Diogo Paramos-de-Carvalho, Maria Adelina Costa, Paulo Correia‐de‐Sá,

Ion channel regulation and function

Pain related to musculoskeletal system is increasingly common and purines, acting through distinct signaling pathways, are described to be involved in nociception (Schleip & Klingler, 2008). Considering that fibroblasts from subcutaneous connective tissue can release adenine or uridine nucleotides, triggering intracellular Ca2+ waves in response to stressful conditions, these cells may play a key role in the propagation/amplification of signals to primary afferent neurons (Furuya et al., 2005). Thus, we decided to investigate the involvement of purinoceptors on bradykinin (BK)-induced activation of fibroblasts of the rat subcutaneous tissue.