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Silane surface modification for improved bioadhesion of esophageal stents

2014; Elsevier BV; Volume: 311; Linguagem: Inglês

10.1016/j.apsusc.2014.05.136

1873-5584

Mert Karakoy, Evin Gultepe, Shivendra Kumar Pandey, Mouen A. Khashab, David H. Gracias,

Tissue Engineering and Regenerative Medicine

Stent migration occurs in 10–40% of patients who undergo placement of esophageal stents, with higher migration rates seen in those treated for benign esophageal disorders. This remains a major drawback of esophageal stent therapy. In this paper, we propose a new surface modification method to increase the adhesion between self-expandable metallic stents (SEMS) and tissue while preserving their removability. Taking advantage of the well-known affinity between epoxide and amine terminated silane coupling agents with amine and carboxyl groups that are abundant in proteins and related molecules in the human body; we modified the surfaces of silicone coated esophageal SEMS with these adhesive self-assembled monolayers (SAMs). We utilized vapor phase silanization to modify the surfaces of different substrates including PDMS strips and SEMS, and measured the force required to slide these substrates on a tissue piece. Our results suggest that surface modification of esophageal SEMS via covalent attachment of protein-binding coupling agents improves adhesion to tissue and could offer a solution to reduce SEMS migration while preserving their removability.