New natural product biosynthetic chemistry discovered by genome mining
2009; Royal Society of Chemistry; Volume: 26; Issue: 8 Linguagem: Inglês
10.1039/b713024b
ISSN1460-4752
AutoresChristophe Corre, Gregory L. Challis,
Tópico(s)Natural product bioactivities and synthesis
ResumoAnalyses of plant and microbial genome sequences have revealed many genes and gene clusters encoding proteins similar to those known to be involved in the biosynthesis of structurally-complex natural products. Many of these genes and gene clusters do not direct the production of known metabolites of the organism in which they are found. Others represent novel gene clusters that direct the biosynthesis of known natural products. This article highlights several examples of new biosynthetic chemistry discovered in the course of investigating such gene clusters.
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