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Retinol levels are associated with magnetic resonance imaging outcomes in multiple sclerosis

2012; SAGE Publishing; Volume: 19; Issue: 4 Linguagem: Inglês

10.1177/1352458512457843

1477-0970

Kristin I. Løken-Amsrud, Kjell‐Morten Myhr, S. J. Bakke, Antonie Giæver Beiske, Kristian S. Bjerve, Bård Bjørnarå, Harald Hovdal, Finn Lilleås, Rune Midgard, Tom Pedersen, Jūratė Šaltytė Benth, Øivind Torkildsen, Stig Wergeland, Trygve Holmøy,

Systemic Lupus Erythematosus Research

Background: Vitamin A has immunomodulatory properties and may regulate the transcription of genes involved in remyelination. Objective: To investigate the association between retinol and disease activity in multiple sclerosis (MS). Methods: Cohort study of 88 relapsing–remitting MS patients, originally included in a randomised placebo-controlled trial of omega-3 fatty acids in MS (the OFAMS study), followed prospectively for 24 months with repeated assessments of serum-retinol and magnetic resonance imaging (MRI). All patients were initiated on interferon β-1a after month 6. Results: Each 1 µmol/L increase in serum-retinol reduced the odds (95% confidence interval) for new T1 gadolinium enhanced (Gd + ) lesions by 49 (8–70)%, new T2 lesions by 42 (2–66)%, and combined unique activity (CUA) by 46 (3–68)% in simultaneous MRI scans, and 63 (25–82)% for new T1Gd + lesions, 49 (3–73)% for new T2 lesions and 43 (12–71)% for CUA the subsequent month. Serum-retinol also predicted new T1Gd + and T2 lesions six months ahead. The associations were not affected by HLA-DRB1*15, or serum levels of 25-hydroxyvitamin D, eicosapentaenoic acid or docosahexaenoic acid. Conclusion: Serum retinol is inversely associated with simultaneous and subsequent MRI outcomes in RRMS.