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Severe Rhabdomyolysis Caused by Plasmodium vivax Malaria in the Brazilian Amazon

2010; American Society of Tropical Medicine and Hygiene; Volume: 83; Issue: 2 Linguagem: Inglês

10.4269/ajtmh.2010.10-0027

1476-1645

André M. Siqueira, Márcia A. A. Alexandre, Maria Paula Gomes Mourão, Valquir Silva dos Santos, Suely K. Nagahashi-Marie, Maria G. C. Alecrim, Marcus Lacerda,

Trypanosoma species research and implications

Severe rhabdomyolysis (creatine phosphokinase = 29,400U/L) developed in a 16-year-old boy from Manaus, Brazil, after he started treatment with chloroquine for infection with Plasmodium vivax . Treatment led to myoglobinuria and acute renal failure. After hemodialysis, the patient improved and a muscle biopsy specimen showed no myophosphorylase or deaminase deficiency. This case of rhabdomyolysis associated with P. vivax infection showed no comorbidities. The pathogenesis is still unclear. Although rhabdomyolysis is generally reported as a complication of Plasmodium falciparum malaria, leading to metabolic and renal complications,1 it has been reported in a patient with P. vivax infection with myoadenylate deaminase deficiency.2 We report a case in a patient without typical muscle enzyme deficiencies in which severe rhabdomyolysis developed while the patients was being treated with chloroquine for a confirmed P. vivax infection.