Activity of Anidulafungin in a Murine Model of Candida krusei Infection: Evaluation of Mortality and Disease Burden by Quantitative Tissue Cultures and Measurement of Serum (1,3)-β- d -Glucan Levels
2009; American Society for Microbiology; Volume: 53; Issue: 4 Linguagem: Inglês
10.1128/aac.00955-08
ISSN1098-6596
AutoresLuis Ostrosky‐Zeichner, Victor L. Paetznick, José C. Rodríguez‐Rey, Enuo Chen, Daniel J. Sheehan,
Tópico(s)Fungal Infections and Studies
ResumoExperience with anidulafungin against Candida krusei is limited. Immunosuppressed mice were injected with 1.3 x 10(7) to 1.5 x 10(7) CFU of C. krusei. Animals were treated with saline, 40 mg/kg fluconazole, 1 mg/kg amphotericin B, or 10 and 20 mg/kg anidulafungin for 5 days. Anidulafungin improved survival and significantly reduced the number of CFU/g in kidneys and serum beta-glucan levels.
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