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Value of Real-Time Elastography Targeted Biopsy for Prostate Cancer Detection in Men With Prostate Specific Antigen 1.25 ng/ml or Greater and 4.00 ng/ml or Less

2010; Lippincott Williams & Wilkins; Volume: 184; Issue: 3 Linguagem: Inglês

10.1016/j.juro.2010.05.026

1527-3792

Friedrich Aigner, Leo Pallwein, Daniel Junker, Georg Schäfer, Gregor Mikuz, Florian Pedross, Michael Josef Mitterberger, Werner Jaschke, Ethan J. Halpern, Ferdinand Frauscher,

Spectroscopy Techniques in Biomedical and Chemical Research

No AccessJournal of UrologyAdult Urology1 Sep 2010Value of Real-Time Elastography Targeted Biopsy for Prostate Cancer Detection in Men With Prostate Specific Antigen 1.25 ng/ml or Greater and 4.00 ng/ml or Less Friedrich Aigner, Leo Pallwein, Daniel Junker, Georg Schäfer, Gregor Mikuz, Florian Pedross, Michael Josef Mitterberger, Werner Jaschke, Ethan J. Halpern, and Ferdinand Frauscher Friedrich AignerFriedrich Aigner Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria More articles by this author , Leo PallweinLeo Pallwein Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria More articles by this author , Daniel JunkerDaniel Junker Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria More articles by this author , Georg SchäferGeorg Schäfer Department of Urology, Medical University of Innsbruck, Innsbruck, Austria More articles by this author , Gregor MikuzGregor Mikuz Department of Pathology, Medical University of Innsbruck, Innsbruck, Austria More articles by this author , Florian PedrossFlorian Pedross Department of Medical Statistics, Informatics and Health, Medical University of Innsbruck, Innsbruck, Austria More articles by this author , Michael Josef MitterbergerMichael Josef Mitterberger Department of Urology, Medical University of Innsbruck, Innsbruck, Austria More articles by this author , Werner JaschkeWerner Jaschke Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria More articles by this author , Ethan J. HalpernEthan J. Halpern Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania More articles by this author , and Ferdinand FrauscherFerdinand Frauscher Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.05.026AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We assessed the prostate cancer detection rate of real-time elastography targeted biopsy in men with total prostate specific antigen 1.25 ng/ml or greater and 4.00 ng/ml or less. Materials and Methods: Real-time elastography using an EUB 8500 Hitachi ultrasound system (Hitachi Medical, Tokyo, Japan) was done in 94 men with a mean age of 57.4 years (range 35 to 77) with increased prostate specific antigen between 1.25 ng/ml or greater and 4.00 ng/ml or less (mean 3.20, range 1.30 to 4.00) and a free-to-total prostate specific antigen ratio of less than 18%. Real-time elastography was done to evaluate peripheral zone tissue elasticity and hard areas were defined as suspicious. Targeted biopsies with a maximum of 5 cores were done in suspicious areas, followed by 10-core systematic biopsy. We analyzed the cancer detection rate of real-time elastography and systematic biopsy. Results: Cancer was found in 27 of 94 patients (28.7%). Real-time elastography detected cancer in 20 patients (21.3%) and systematic biopsy detected it in 18 (19.1%). Positive cancer cores were found in real-time elastography targeted cores in 38 of 158 cases (24%) and in systematic cores in 38 of 752 (5.1%) (chi-square test p <0.0001). The cancer detection rate per core was 4.7-fold greater for targeted than for systematic biopsy. Conclusions: Real-time elastography targeted biopsy allows prostate cancer detection in men with prostate specific antigen 1.25 ng/ml or greater and 4 ng/ml or less with a decreased number of cores compared with that of systematic biopsy. References 1 : Cancer statistics, 2009. CA Cancer J Clin2009; 59: 225. Google Scholar 2 : EAU guidelines on prostate cancer: European Association of Urology. Eur Urol2005; 48: 546. Google Scholar 3 : Early detection of prostate cancer. Hum Pathol1992; 23: 211. Google Scholar 4 : Ultrasound of the Prostate. Philadelphia: Lippincott-Raven1997. Google Scholar 5 : Early detection of prostate cancer in 2007: Part 1: PSA and PSA kinetics. Eur Urol2008; 53: 468. 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Link, Google Scholar © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited bySchiffmann J, Grindei M, Tian Z, Yassin D, Steinwender T, Leyh-Bannurah S, Randazzo M, Kwiatkowski M, Karakiewicz P, Hammerer P and Manka L (2018) Limitations of Elastography Based Prostate BiopsyJournal of Urology, VOL. 195, NO. 6, (1731-1736), Online publication date: 1-Jun-2016.Brock M, von Bodman C, Palisaar R, Löppenberg B, Sommerer F, Deix T, Noldus J and Eggert T (2018) The Impact of Real-Time Elastography Guiding a Systematic Prostate Biopsy to Improve Cancer Detection Rate: A Prospective Study of 353 PatientsJournal of Urology, VOL. 187, NO. 6, (2039-2043), Online publication date: 1-Jun-2012. Volume 184Issue 3September 2010Page: 913-917 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.Keywordselasticity imaging techniquesprostatebiopsyprostate-specific antigenprostatic neoplasmsMetricsAuthor Information Friedrich Aigner Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria More articles by this author Leo Pallwein Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria More articles by this author Daniel Junker Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria More articles by this author Georg Schäfer Department of Urology, Medical University of Innsbruck, Innsbruck, Austria More articles by this author Gregor Mikuz Department of Pathology, Medical University of Innsbruck, Innsbruck, Austria More articles by this author Florian Pedross Department of Medical Statistics, Informatics and Health, Medical University of Innsbruck, Innsbruck, Austria More articles by this author Michael Josef Mitterberger Department of Urology, Medical University of Innsbruck, Innsbruck, Austria More articles by this author Werner Jaschke Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria More articles by this author Ethan J. Halpern Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania More articles by this author Ferdinand Frauscher Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria More articles by this author Expand All Advertisement PDF downloadLoading ...