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The effect of inhaled nitric oxide therapy on bleeding time and platelet aggregation in neonates

1998; Elsevier BV; Volume: 132; Issue: 4 Linguagem: Inglês

10.1016/s0022-3476(98)70370-1

1097-6833

T. Neville George, Karen Johnson, James N. Bates, Jeffrey L. Segar,

Neuroscience of respiration and sleep

The effect of inhaled nitric oxide (iNO) on bleeding time and platelet aggregation was studied in nine newborn infants with resolving pulmonary hypertension. Infants treated with iNO at 40 ppm for 30 minutes had bleeding times that were nearly twofold longer than those obtained 24 hours after iNO was discontinued. iNO had no effect on in vitro platelet aggregation studies.