Comparison of Maternal and Newborn Serologic Tests for Syphilis

1991; American Medical Association; Volume: 145; Issue: 12 Linguagem: Inglês

10.1001/archpedi.1991.02160120051018

ISSN

1538-3628

Autores

Sarah A. Rawstron, Kenneth Bromberg,

Tópico(s)

Prenatal Screening and Diagnostics

Resumo

• Objective. —To compare the cord blood, newborn serum, and maternal serum for the diagnosis of congenital syphilis. Design. —Retrospective chart review. Setting. —Kings County Hospital Center, Brooklyn, NY. Patients. —Three hundred forty-eight mother-newborn pairs with positive syphilis serology. Measurements and Results. —One hundred fifteen newborns (33%) had rapid plasma reagin tests of cord blood that were nonreactive. Their mothers had positive serologic findings. There were 10% false-positive cord blood samples (cord blood rapid plasma reagin tests reactive, newborn serum rapid plasma reagin tests nonreactive) and 5% false-negative cord blood samples (cord rapid plasma reagin tests nonreactive, newborn serum rapid plasma reagin tests reactive). Thirty-three newborns had congenital syphilis. Seven newborns had cord titers fourfold higher than their mothers'; only four of these newborns had congenital syphilis. Maternal serology is superior to cord blood analysis for identifying newborns at risk of congenital syphilis. ( AJDC. 1991;145:1383-1388)

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