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Cushing's Disease Associated with an lntrasellar Gangliocytoma Producing Corticotrophin-Releasing Factor

1984; American College of Physicians; Volume: 101; Issue: 6 Linguagem: Inglês

10.7326/0003-4819-101-6-789

1539-3704

L. Sylvia,

Peripheral Neuropathies and Disorders

Short Papers1 December 1984Cushing's Disease Associated with an lntrasellar Gangliocytoma Producing Corticotrophin-Releasing FactorSYLVIA L. ASA, M.D., KALMAN KOVACS, M.D., Ph.D., GEORGE T. TINDALL, M.D., DANIEL L. BARROW, M.D., EVA HORVATH, Ph.D., PAUL VECSEI, M.D.SYLVIA L. ASA, M.D., KALMAN KOVACS, M.D., Ph.D., GEORGE T. TINDALL, M.D., DANIEL L. BARROW, M.D., EVA HORVATH, Ph.D., PAUL VECSEI, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-6-789 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA 58-year-old woman had Cushing's disease with elevated plasma adrenocorticotrophin and an intrasellar tumor. Light microscopy showed that the tumor was a gangliocytoma containing immunoreactive corticotrophinreleasing factor accompanied by pituitary corticotroph hyperplasia. Ultrastructural examination identified an intimate association and desmosomal attachments between interdigitating cell processes of neurons and corticotrophs. It is suggested that Cushing's disease was due to the effect of corticotrophin-releasing factor on corticotrophs; this case represents a syndrome supporting the concept that, in some patients, Cushing's disease may have a hypothalamic origin....References1. CUSHING H. The basophil adenomas of the pituitary body and their clinical manifestations (pituitary basophilism). Bull Johns Hopkins Hosp. 1932;50:137-95. Google Scholar2. ROBERTPELLETIERHARDY FGJ. Pituitary adenomas in Cushing's disease: a histologic, ultrastructural, and immunocytochemical study. Arch Pathol Lab Med. 1978;102:448-55. MedlineGoogle Scholar3. SALASSALAWSCARPENTERNORTHCUTT REPR. Transsphenoidal removal of pituitary microadenoma in Cushing's disease. Mayo Clin Proc. 1978;53:24-8. MedlineGoogle Scholar4. TYRRELLBROOKSFITZGERALDCOFOIDFORSHAMWILSON JRPPPC. 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Author, Article, and Disclosure InformationAffiliations: Toronto, Ontario, Canada Atlanta, Georgia; and Heidelberg, Federal Republic of Germany▸From the Department of Pathology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; the Department of Surgery, Division of Neurosurgery, Emory University, Atlanta, Georgia; and the Department of Pharmacology, University of Heidelberg, Heidelberg, Federal Republic of Germany. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHypothalamic Neuroendocrine NeoplasmsNeuroendocrine Neoplasms and Lesions of the HypothalamusHypothalamic hormone-producing tumorsPituitary Gangliocytoma Producing TSH and TRH: A Review of "Gangliocytomas of the Sellar Region"Eje hipotálamo hipofisario. 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