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Co‐expression of endothelial cell and macrophage antigens in Kaposi's sarcoma cells

1994; Volume: 173; Issue: 1 Linguagem: Inglês

10.1002/path.1711730105

1096-9896

Stefania Uccini, Luigi Ruco, Francesca Monardo, Antonella Stoppacciaro, Elisabetta Dejana, Ilaria Lesnoni La Parola, D. Cerimele, Carlo D. Baroni,

Immunotherapy and Immune Responses

Abstract The histopathogenesis of Kaposi's sarcoma (KS) was investigated using immunocytochemistry in 12 skin biopsies obtained from two AIDS patients, nine patients with the classic form, and one organ‐transplant patient. KS cells revealed a peculiar antigenic profile, being characterized by co‐expression of endothelial and macrophage markers. KS cells were stained for von Willebrand factor (vWF); for vascular endothelial (VE) cadherin, an endothelial specific adhesion molecule; and for PECAM/CD31. In addition, they expressed the macrophage antigens PAM‐1, CD68, and CD14, and were positive for vitronectin receptor and alpha‐1,5,6/beta‐1 integrins. KS cells were weakly stained for ICAM‐1 in 6 of 12 cases and were negative for VCAM‐1 and E‐selectin.