Mixing in liquid‐impelled loop reactors
1992; Wiley; Volume: 39; Issue: 7 Linguagem: Inglês
10.1002/bit.260390703
ISSN1097-0290
AutoresH. M. van Sonsbeek, S. P. Van Der Tuin, J. Tramper,
Tópico(s)Process Optimization and Integration
ResumoAbstract The liquid‐impelled loop reactor is a new column‐type bioreactor. The design of this device is based on the principle of the air‐lift loop reactor. In the external‐loop configuration used in this work, descending perfluorochemical drops bring about circulation of the continuous aqueous phase. Mixing of this continuous phase is characterized per section of the rector. Axial‐dispersion coefficients for the tube with two‐phase flow are determined and correlated with the energy dissipation in the tube. Comparisons with similar systems such as bubble columns and air‐lift loop reactors are made. Overall mixing parameters are derived and used for calculation of the number of circulatins needed to achieve a certain degree of mixing. The hydrodynamic model from previous work is tested for the reactor configurations of this work. It can be useful to calculate circulation times.
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