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Effect of thiadiazine derivatives on intracellular amastigotes of Leishmania amazonensis

2004; Instituto Oswaldo Cruz, Ministério da Saúde; Volume: 99; Issue: 3 Linguagem: Inglês

10.1590/s0074-02762004000300016

1678-8060

Lianet Monzote Fidalgo, Ana Margarita Montalvo Álvarez, Lisset Fonseca Géigel, Rolando Pérez, Margarita Suárez Navarro, Hortensia Rodríguez Cabrera,

Synthesis and biological activity

Current therapy for leishmaniasis is not satisfactory. We describe the in vitro antiproliferative effects of new thiadiazine derivatives against Leishmania amazonensis. The compounds were found to be active against the amastigote form of the parasite, inhibiting parasite growing, from 10 to 89%, at a concentration of 100 ng/ml. This activity suggests that thiadiazine derivatives could be considered as potential antileishmanial compounds.