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Bulimic Vomiting Alters Pain Tolerance and Mood

1987; SAGE Publishing; Volume: 16; Issue: 4 Linguagem: Inglês

10.2190/qg04-42ku-mkvr-crht

1541-3527

Henry David Abraham, Anthony B. Joseph,

Biochemical effects in animals

Bulimia, a disorder of episodic bulging and purging, remains without a known etiology. A case report is presented of a patient who attributed bulimic episodes to efforts at inducing euphoria. Experimental pain tolerance was increased by bulimic vomiting, blocked by naloxone, but not by saline. Vomiting was also associated with falls in depression and anxiety. Plasma ACTH and Cortisol, putative markers for β-endorphin, also rose following vomiting. It is hypothesized that in some bulimics, the disorder arises by virtue of an addiction to one's own internally released endogenous opioid peptides.