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Mycophenolic acid versus azathioprine as primary immunosuppression for kidney transplant recipients

2015; Elsevier BV; Volume: 2015; Issue: 12 Linguagem: Inglês

10.1002/14651858.cd007746.pub2

1465-1858

Martin Wagner, Amy Earley, Angela C Webster, Christopher H. Schmid, Ethan M. Balk, Katrin Uhlig,

Polyomavirus and related diseases

Modern immunosuppressive regimens after kidney transplantation usually use a combination of two or three agents of different classes to prevent rejection and maintain graft function. Most frequently, calcineurin-inhibitors (CNI) are combined with corticosteroids and a proliferation-inhibitor, either azathioprine (AZA) or mycophenolic acid (MPA). MPA has largely replaced AZA as a first line agent in primary immunosuppression, as MPA is believed to be of stronger immunosuppressive potency than AZA. However, treatment with MPA is more costly, which calls for a comprehensive assessment of the comparative effects of the two drugs.