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The Genome of the Natural Genetic Engineer Agrobacterium tumefaciens C58

2001; American Association for the Advancement of Science; Volume: 294; Issue: 5550 Linguagem: Inglês

10.1126/science.1066804

1095-9203

Derek W. Wood, João Carlos Setúbal, Rajinder Kaul, Dave E. Monks, João Paulo Kitajima, Vagner Katsumi Okura, Yang Zhou, Lishan Chen, Gwendolyn E. Wood, Nalvo F. Almeida, Lisa Woo, Yuching Chen, Ian T. Paulsen, Jonathan A. Eisen, Peter D. Karp, Donald Bovee, Peter D. Chapman, James B. Clendenning, Glenda Deatherage, Will Gillet, Charles E. Grant, Tatyana Kutyavin, Ruth Levy, Meng-Jin Li, Erin K. McClelland, Anthony Palmieri, Christopher K. Raymond, G. Rouse, Channakhone Saenphimmachak, Zaining Wu, Pedro Romero, David Gordon, Shiping Zhang, Heayun Yoo, Yumin Tao, Phyllis Biddle, Mark Jung, William Krespan, M. Perry, Bill Gordon‐Kamm, Li Liao, Sun Kim, Carol A. Hendrick, Zuo‐Yu Zhao, Maureen Dolan, Forrest G. Chumley, Scott Tingey, Jean-François Tomb, Milton P. Gordon, Maynard V. Olson, Eugene W. Nester,

Plant nutrient uptake and metabolism

The 5.67-megabase genome of the plant pathogen Agrobacterium tumefaciens C58 consists of a circular chromosome, a linear chromosome, and two plasmids. Extensive orthology and nucleotide colinearity between the genomes of A. tumefaciens and the plant symbiont Sinorhizobium meliloti suggest a recent evolutionary divergence. Their similarities include metabolic, transport, and regulatory systems that promote survival in the highly competitive rhizosphere; differences are apparent in their genome structure and virulence gene complement. Availability of the A. tumefaciens sequence will facilitate investigations into the molecular basis of pathogenesis and the evolutionary divergence of pathogenic and symbiotic lifestyles.