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Oxidative Stress and Epilepsy: Literature Review

2012; Hindawi Publishing Corporation; Volume: 2012; Linguagem: Inglês

10.1155/2012/795259

1942-0900

Carlos Clayton Torres Aguiar, Anália Barbosa Almeida, Paulo Victor Pontes Araújo, Rita Neuma Dantas Cavalcante de Abreu, Edna Maria Camelo Chaves, Otoni Cardoso do Vale, Danielle S. Macêdo, David Woods, Marta Maria de França Fonteles, Silvânia Maria Mendes Vasconcelos,

Metabolism and Genetic Disorders

Backgrounds . The production of free radicals has a role in the regulation of biological function, cellular damage, and the pathogenesis of central nervous system conditions. Epilepsy is a highly prevalent serious brain disorder, and oxidative stress is regarded as a possible mechanism involved in epileptogenesis. Experimental studies suggest that oxidative stress is a contributing factor to the onset and evolution of epilepsy. Objective . A review was conducted to investigate the link between oxidative stress and seizures, and oxidative stress and age as risk factors for epilepsy. The role of oxidative stress in seizure induction and propagation is also discussed. Results/Conclusions . Oxidative stress and mitochondrial dysfunction are involved in neuronal death and seizures. There is evidence that suggests that antioxidant therapy may reduce lesions induced by oxidative free radicals in some animal seizure models. Studies have demonstrated that mitochondrial dysfunction is associated with chronic oxidative stress and may have an essential role in the epileptogenesis process; however, few studies have shown an established link between oxidative stress, seizures, and age.